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Source of protection against saturated fat (Angptl4) found, and 3% of people don't have it. |
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EurekAlert: The data show that Angptl4 is a key player in the protection against the severe proinflammatory effects of dietary saturated fat, the researchers conclude. The findings may have implications for the approximately three percent of the human population who carry a mutation in the Angptl4 gene. "Based on our data in mice, it can be hypothesized that human subjects homozygous for the E40K mutation in Angptl4, which has reduced ability to inhibit LPL and is associated with lower plasma triglycerides, may be particularly sensitive to the proinflammatory effects of dietary saturated fat," the researchers wrote.
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