| Pharmacokinetics and tolerability of zibotentan (ZD4054) in subjects with ... - 7thSpace Interactive (press release) |
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7thSpace Interactive (press release) As zibotentan is eliminated by renal and metabolic routes, clearance may be reduced in patients with hepatic or renal impairment, leading to greater drug exposure. Methods: Open-label studies investigated the PK and tolerability of zibotentan in |