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New gene mutation that is commonly associated with renal cell cancer discovered.

Science Blog: In a collaborative project involving scientists from three continents, researchers have identified a gene that is mutated in one in three patients with the most common form of renal cancer. The gene — called PBRM1 — was found to be mutated in 88 cases out of 257 clear cell renal cell carcinomas (ccRCC) analysed, making it the most prevalent to be identified in renal cancer in 20 years.

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CMS organizes MEDCAC meeting to assess ESAs in transplant patients

CMS: Erythropoiesis Stimulating Agents (ESAs) for Treatment of Anemia in Adults with CKD Including Patients on Dialysis and Patients not on Dialysis: The Impact of ESA Use on Renal Transplant Graft Survival ........................... CMS has called this meeting of the panel to review the available evidence on the use of erythropoiesis stimulating agents (ESAs) to affect renal (kidney) transplant graft survival in patients who have both chronic kidney disease (CKD) and anemia. Some parties claim that prior ESA use may predict the long term success of subsequent renal transplantation in patients with CKD.

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FDA to streamline path for medical device review.

FDA: The U.S. Food and Drug Administration today unveiled a plan containing 25 actions it intends to implement during 2011 to improve the most common path to market for medical devices. Key actions include: ........................ * Streamlining the “de novo” review process for certain innovative, lower-risk medical devices,................... * Clarifying when clinical data should be submitted in a premarket submission, guidance that will increase the efficiency and transparency of the review process,..................... * Establishing a new Center Science Council of senior FDA experts to assure timely and consistent science-based decision making.

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Mutated Gene Found in Patients with Most Common Form of Renal Cancer - eMaxHealth

eMaxHealth
Renal cancer is among the 10 most common cancers in both men and women in the United States. Renal Cell Carcinoma (RCC) accounts for 90% of kidney cancer

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MedCAC Unsure on ESA Use in Kidney Transplants - MedPage Today

MedPage Today
Judging from presentations to the panel, it is common practice for nephrologists to use ESAs -- including epoetin alfa (Procrit and Epogen) and darbepoetin

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