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NEJM: rTPA use lowers risk on infection and sepsis in dialysis patients with CVCs. |
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NEJM: Dr. Brenda Hemmelgarn from the University of Calgary Faculty of Medicine and her colleague Dr. Nairne Scott-Douglas, both members of the Libin Cardiovascular Institute of Alberta, undertook a randomized trial at 11 sites across Canada. 115 hemodialysis patients were administered the usual catheter locking solution of heparin after every dialysis session, while 110 patients received rt-PA once a week. Researchers found that those receiving only heparin were twice as likely to suffer a catheter malfunction and were at an almost three-fold increased risk of blood stream infection.
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